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1Q84 audiobook. Interview by John Freeman.Ultrastructural changes in discrete structures of dentine matrix and peritubular dentine during physiological odontoblast differentiation in the rat incisor.
The ultrastructural changes in the matrix and peritubular dentine of odontoblasts during physiological dentine matrix maturation are described. In odontoblasts of rat incisor, the initial step of dentine matrix maturation is characterized by a progressive increase in electron dense matrix granules (EMGs) and a simultaneous increase in dentine tubules of an incipient "unorganized" type. Post-secretory maturation is marked by a progressive decrease in EMGs and a progressive increase in tubules in both the peritubular and organic dentine. The average size of the EMGs gradually increases and begins to show obvious intergranular space. This initial stage of maturation can be followed by either disintegration of electron opaque product or cross-linking of matrix material. The changes observed in matrix and peritubular dentine, when viewed over time, indicate that matrix maturation of 0b46394aab